THANDIWE DUBE
Senior Research Scientist
South San Francisco, CA · t.dube@email.com · (555) 214-7890
Summary
Senior research scientist with 10+ years in oncology drug discovery, leading cross-functional teams from target validation through IND-enabling studies. Author of 14 peer-reviewed publications and recipient of $3.2M in competitive grant funding.
Experience
Senior Research Scientist · Genentech
2019 - Present
- Led a 6-person lab investigating novel kinase inhibitors, advancing 2 candidates to IND-enabling studies
- Secured $1.8M in internal translational research funding by presenting preclinical data to executive review board
- Designed and validated a high-throughput screening assay that reduced hit-identification time by 35%
- Mentors 4 junior scientists and 2 interns; 3 promoted to independent project leads
- Chairs the site data-integrity committee, cutting repeat experiments 22% across 9 teams
Postdoctoral Research Fellow · Broad Institute of MIT and Harvard
2015 - 2019
- Published 6 first-author papers on tumor microenvironment signaling in journals including Cell and Nature Communications
- Secured a $450K NIH K99/R00 award to fund independent research transition
- Built a CRISPR-Cas9 screen of 18,000 guides mapping immune-evasion dependencies
- Analyzed single-cell RNA-seq in R and Seurat, defining 7 unreported stromal subtypes
Graduate Research Assistant · Harvard University, Department of Molecular and Cellular Biology
2010 - 2015
- Characterized 3 novel ubiquitin ligase substrates via CRISPR-Cas9 knockouts and mass spec
- Maintained 40+ cell lines and set culture protocols adopted by an 11-member laboratory
- Presented dissertation research at 5 national conferences, including the AACR Annual Meeting
Education
Ph.D. Molecular and Cellular Biology — Harvard University · 2015
Skills
Experimental Design, CRISPR-Cas9, Flow Cytometry, Western Blot, Cell Culture, Grant Writing, R, Python, GraphPad Prism, Protein Purification, ELISA, Team Leadership
Certifications
Responsible Conduct of Research (RCR), CITI Program
Working with the IACUC, CITI Program
Registered Biosafety Professional (RBP), ABSA International
Projects
Kinase Inhibitor Atlas - open dataset of 240 compound-target profiles, cited in 30+ papers
TumorScope - R package for single-cell tumor microenvironment clustering, 1,200 downloads
Assay QC Dashboard - Python and Streamlit tool tracking plate variance across 60 screens
Languages
English (Native), Zulu (Native), French (Professional Working)
Interests
Science outreach in schools, Long-distance running, Botanical illustration, Chess




